Regul Pept 49:195–202īiancotti L, Elverdin JC, Vatta MS, Fernández BE (1996) Atrial natriuretic factor modifies the composition of induced salivary secretion in the rat. This process is experimental and the keywords may be updated as the learning algorithm improves.īiancotti L, Elverdin JC, Vatta MS, Colatrella C, Fernández BE (1994) Atrial natriuretic factor enhances induced salivary secretion in the rat. These keywords were added by machine and not by the authors. Gastrin-releasing Peptide Receptor (GRP-R).injection by placing and holding a pre-weighed, absorbent foam cube (e.g. The rat's oral cavity is swabbed immediately after i.v. Conscious rats are injected i.v., via the lateral tail vein, with either the vehicle or the sialagogue, e.g., substance P (0.3–3 μg/kg in 1 ml saline/kg). 1.1.2 PROCEDUREįed, male Sprague-Dawley rats (200–300 g) are weighed and distributed randomly into groups of 6 animals. (1991) proposed a simple method to study saliva secretion in conscious rats and to evaluate sialagogues and sialagogue antagonists. Saliva excretion is greatly influenced by anesthetics.
Studies to find and to evaluate sialagogues, such as substance P and its synthetic derivatives, as well as to search for salivation inhibitors are necessary. Symptoms of several human diseases are manifested as increased salivation (e.g., Parkinson's disease) or decreased salivation (e.g., xerosis). MacOS 11.0 or later.1.1 J.1.0.1 Measurement of salivation 1.1.1 PURPOSE AND RATIONALE
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